Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27553112 | 0.95 | TSHR (0.48) | TSHRALDH1A1TP53THRBTDP1 | |
| SCHEMBL20364 | 0.95 | — | — | |
| SCHEMBL10762910 | 0.95 | — | — | |
| SCHEMBL11125870 | 0.95 | — | — | |
| Methacrylic Acid SCHEMBL2337043 | 0.93 | TSHR (0.43) | TSHRALDH1A1TP53THRBTDP1 | |
| Methacrylic Acid SCHEMBL28768411 | 0.93 | TSHR (0.43) | TSHRALDH1A1TP53THRBTDP1 | |
| Ethylene SCHEMBL8934253 | 0.93 | TSHR (0.46) | TSHRALDH1A1THRBTDP1 | |
| Water SCHEMBL10713209 | 0.93 | TSHR (0.46) | TSHRALDH1A1THRBTDP1 | |
| SCHEMBL20701419 | 0.93 | TSHR (0.46) | TSHRALDH1A1THRBTDP1 | |
| Acetone SCHEMBL8653588 | 0.93 | TSHR (0.46) | TSHRALDH1A1THRBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9717672-B2 | Compositions and methods for UV-curable cosmetic nail coatings | CREATIVE NAIL DESIGN, INC. (US) | 2017-08-01 | — | — | US | claimed |
| US-20160038400-A1 | COMPOSITIONS AND METHODS FOR UV-CURABLE COSMETIC NAIL COATINGS | MUFG BANK LTD. AS AGENT | 2016-02-11 | — | — | US | claimed |
| US-8901199-B2 | Compositions and methods for UV-curable cosmetic nail coatings | CREATIVE NAIL DESIGN, INC. (US) | 2014-12-02 | — | — | US | claimed |
| EP-2683350-A1 | COMPOSITIONS AND METHODS FOR UV-CURABLE COSMETIC NAIL COATINGS | Creative Nail Design, Inc. (US) | 2014-01-15 | — | — | EP | claimed |
| WO-2012121704-A1 | COMPOSITIONS AND METHODS FOR UV-CURABLE COSMETIC NAIL COATINGS | CREATIVE NAIL DESIGN, INC. (US) | 2012-09-13 | — | — | WO | claimed |
| US-20110274633-A1 | COMPOSITIONS AND METHODS FOR UV-CURABLE COSMETIC NAIL COATINGS | COLOMER USA (US) | 2011-11-10 | — | — | US | claimed |
| US-10603264-B2 | Silsesquioxanes and use in nail coatings thereof | REVLON CONSUMER PRODUCTS CORPORATION (US) | 2020-03-31 | — | — | US | disclosed |
| US-20190192411-A1 | SILSESQUIOXANES AND USE IN NAIL COATINGS THEREOF | MUFG BANK LTD. AS AGENT | 2019-06-27 | — | — | US | disclosed |
| US-9717672-B2 | Compositions and methods for UV-curable cosmetic nail coatings | CREATIVE NAIL DESIGN, INC. (US) | 2017-08-01 | — | — | US | disclosed |
| US-9713585-B2 | Nail coatings having enhanced adhesion | CREATIVE NAIL DESIGN, INC. (US) | 2017-07-25 | — | — | US | disclosed |
| US-20170056313-A1 | NAIL COATINGS HAVING ENHANCED ADHESION | CREATIVE NAIL DESIGN, INC. (US) | 2017-03-02 | — | — | US | disclosed |
| US-20160067164-A1 | NAIL COATINGS HAVING ENHANCED ADHESION | MUFG BANK LTD. AS AGENT | 2016-03-10 | — | — | US | disclosed |
| EP-2988721-A1 | NAIL COATINGS HAVING ENHANCED ADHESION | Creative Nail Design, Inc. (US) | 2016-03-02 | — | — | EP | disclosed |
| US-20150044150-A1 | COMPOSITIONS AND METHODS FOR UV-CURABLE COSMETIC NAIL COATINGS | CREATIVE NAIL DESIGN, INC. | 2015-02-12 | — | — | US | disclosed |
| US-8901199-B2 | Compositions and methods for UV-curable cosmetic nail coatings | CREATIVE NAIL DESIGN, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| WO-2014176275-A1 | NAIL COATINGS HAVING ENHANCED ADHESION | CREATIVE NAIL DESIGN, INC. (US) | 2014-10-30 | — | — | WO | disclosed |
| EP-2683350-A1 | COMPOSITIONS AND METHODS FOR UV-CURABLE COSMETIC NAIL COATINGS | Creative Nail Design, Inc. (US) | 2014-01-15 | — | — | EP | disclosed |
| CN-103501755-A | Compositions and methods for UV-curable cosmetic nail coatings | CREATIVE NAIL DESIGN INC | 2014-01-08 | — | — | CN | disclosed |
| WO-2012121704-A1 | COMPOSITIONS AND METHODS FOR UV-CURABLE COSMETIC NAIL COATINGS | CREATIVE NAIL DESIGN, INC. (US) | 2012-09-13 | — | — | WO | disclosed |
| US-20110274633-A1 | COMPOSITIONS AND METHODS FOR UV-CURABLE COSMETIC NAIL COATINGS | COLOMER USA (US) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190192411-A1 | SILSESQUIOXANES AND USE IN NAIL COATINGS THEREOF | POLR1C, BMI1, DPM1 | TSHR 2403/4885ALDH1A1 208/4885TP53 2956/4885 |
| US-10603264-B2 | Silsesquioxanes and use in nail coatings thereof | POLR1C, BMI1, DPM1 | TSHR 2403/4885ALDH1A1 208/4885TP53 2956/4885 |
| US-20160067164-A1 | NAIL COATINGS HAVING ENHANCED ADHESION | PIK3C3, POLR1C, NACA | TSHR 3794/4885ALDH1A1 2316/4885TP53 1016/4885 |
| US-20170056313-A1 | NAIL COATINGS HAVING ENHANCED ADHESION | POLR1C, PIK3C3, NACA | TSHR 4023/4885ALDH1A1 1567/4885TP53 1596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.