Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 6/20 | 0.39 |
| ▸ | BRAF | P15056 | 6/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | TET3 | O43151 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6637819 | 0.87 | MEN1 (0.39) | PROKR1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL1759894 | 0.85 | KDM4C (0.55) | PROKR1ALDH1A1KDM4CMAPTKDM4E | |
| SCHEMBL12136051 | 0.83 | SMARCA2 (0.49) | MEN1KMT2ARAF1BRAFALDH1A1 | |
| SCHEMBL30418990 | 0.83 | KDM5C (0.44) | PROKR1CYP1A2CYP3A4KDM4CKDM5A | |
| SCHEMBL6047032 | 0.83 | KDM5C (0.44) | PROKR1CYP1A2CYP3A4KDM4CKDM5A | |
| SCHEMBL13130439 | 0.80 | PROKR1 (0.41) | PROKR1KMT2ACYP1A2CYP3A4RAF1 | |
| SCHEMBL28298259 | 0.80 | MEN1 (0.37) | MEN1KMT2ACYP1A2CYP3A4RAF1 | |
| SCHEMBL14566838 | 0.80 | PLK1 (0.46) | PROKR1MEN1KMT2ARAF1BRAF | |
| SCHEMBL8953772 | 0.80 | KDM4E (0.57) | PROKR1CYP1A2CYP3A4ALDH1A1NPC1 | |
| SCHEMBL30007857 | 0.79 | KDM4E (0.50) | PROKR1MEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234950-A1 | CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234950-A1 | CRBN LIGANDS AND USES THEREOF | CRBN, CRKL, ERBB3 | PROKR1 2271/4885MEN1 2201/4885KMT2A 2436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.