Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 6/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | BMX | P51813 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25900139 | 0.87 | TIPARP (0.56) | TIPARPCHEK1FLT3KITKDR | |
| SCHEMBL25899853 | 0.84 | TIPARP (0.60) | TIPARPCHEK1FLT3KITHDAC1 | |
| SCHEMBL26787748 | 0.83 | TIPARP (0.59) | TIPARPCHEK1FLT3KITHDAC1 | |
| SCHEMBL25900587 | 0.83 | TIPARP (0.40) | TIPARPCHEK1FLT3AURKANTRK1 | |
| SCHEMBL25900208 | 0.81 | TIPARP (0.54) | TIPARPCHEK1FLT3AURKANTRK1 | |
| SCHEMBL25902165 | 0.81 | TIPARP (0.54) | TIPARPCHEK1FLT3AURKANTRK1 | |
| SCHEMBL25907752 | 0.81 | TIPARP (0.53) | TIPARPCHEK1FLT3AURKANTRK1 | |
| SCHEMBL25900854 | 0.80 | TIPARP (0.56) | TIPARPCHEK1FLT3AURKANTRK1 | |
| SCHEMBL25903813 | 0.79 | BRD9 (0.37) | TIPARPHDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL25903517 | 0.76 | TIPARP (0.46) | TIPARPCHEK1FLT3AURKANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023147418-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2023-08-03 | — | — | WO | disclosed |