Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 6/20 | 0.59 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 4/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25899853 | 0.99 | TIPARP (0.60) | TIPARPTLR8FLT3CHEK1KDM4E | |
| SCHEMBL25900139 | 0.93 | TIPARP (0.56) | TIPARPFLT3CHEK1LMNASMN1; SMN2 | |
| SCHEMBL25908010 | 0.89 | TIPARP (0.65) | TIPARPFLT3CHEK1KITTNF | |
| SCHEMBL25899897 | 0.89 | TIPARP (0.51) | TIPARPTLR8KDM4ESMN1; SMN2HDAC3 | |
| SCHEMBL25900854 | 0.88 | TIPARP (0.56) | TIPARPFLT3CHEK1KITKDR | |
| SCHEMBL25899923 | 0.86 | TIPARP (0.49) | TIPARPFLT3CHEK1KDM4ELMNA | |
| SCHEMBL25898542 | 0.86 | TIPARP (0.48) | TIPARPTLR8KDM4ELMNAMAPT | |
| SCHEMBL26796438 | 0.85 | TIPARP (0.45) | TIPARPTLR8FLT3CHEK1KDM4E | |
| SCHEMBL25899908 | 0.85 | TIPARP (0.51) | TIPARPTLR8KDM4ESMN1; SMN2HDAC3 | |
| SCHEMBL25897832 | 0.85 | TIPARP (0.49) | TIPARPTLR8KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365529-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. | 2023-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365529-A1 | PARP7 INHIBITORS | PARP1, PARP11, PARP2 | TIPARP 491/4885TLR8 2856/4885FLT3 2225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.