Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.53 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.42 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695589 | 0.75 | NPC1 (0.52) | GPR119PTPN1 | |
| SCHEMBL12396694 | 0.71 | TLR7 (0.80) | GPR119TLR7PTPN1CHRNB4CHRNA3 | |
| SCHEMBL2587313 | 0.70 | GPR119 (1.00) | GPR119 | |
| SCHEMBL141648 | 0.68 | SMN1; SMN2 (0.48) | GPR119PTPN1 | |
| SCHEMBL27652500 | 0.68 | HDAC6 (0.47) | GPR119PTPN1 | |
| SCHEMBL12396693 | 0.68 | TLR7 (0.91) | GPR119TLR7PTPN1CHRNB4CHRNA3 | |
| SCHEMBL29526066 | 0.68 | TLR7 (0.91) | GPR119TLR7PTPN1CHRNB4CHRNA3 | |
| SCHEMBL145632 | 0.68 | SMN1; SMN2 (0.49) | GPR119PTPN1 | |
| SCHEMBL12396692 | 0.66 | TLR7 (0.83) | GPR119TLR7PTPN1TLR9 | |
| SCHEMBL12397217 | 0.66 | TLR7 (0.83) | GPR119TLR7PTPN1TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566864-A2 | PYRIDAZINONES AS GPR119 AGONISTS | Boehringer Ingelheim International GmbH (DE) | 2013-03-13 | — | — | EP | claimed |
| WO-2011138427-A2 | PYRIDAZINONES AS GPR119 AGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-10 | — | — | WO | claimed |