Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 10/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24954404 | 0.93 | TIPARP (0.52) | TIPARPPARP1HDAC1HDAC6 | |
| SCHEMBL25912405 | 0.84 | TIPARP (0.45) | TIPARPPARP1 | |
| SCHEMBL26184588 | 0.78 | TIPARP (0.45) | TIPARPPDE3BPDE3APARP1KDM4E | |
| SCHEMBL25010037 | 0.77 | TIPARP (0.43) | TIPARPPARP1 | |
| SCHEMBL25907829 | 0.74 | TIPARP (0.47) | TIPARP | |
| SCHEMBL26298693 | 0.73 | TIPARP (0.65) | TIPARPPDE3BPDE3AKDM4EMEN1 | |
| SCHEMBL30196255 | 0.73 | TIPARP (0.46) | TIPARPPARP1HDAC1HDAC6 | |
| SCHEMBL9413547 | 0.71 | ALDH1A1 (0.48) | PARP1KDM4EMEN1APAF1ALDH1A1 | |
| SCHEMBL24640950 | 0.71 | TIPARP (0.47) | TIPARPPARP1 | |
| SCHEMBL28883351 | 0.71 | PTGS1 (0.45) | PTGS1PTGS2KDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023147418-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2023-08-03 | — | — | WO | disclosed |