Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24464111 | 0.88 | LMNA (0.72) | NPSR1CYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL3755623 | 0.78 | KDM4E (0.60) | NPSR1CYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL20585096 | 0.77 | HTT (0.67) | LMNATSHRPOLBALDH1A1RAB9A | |
| SCHEMBL20585329 | 0.76 | HTT (0.66) | LMNATSHRPOLBMEN1KMT2A | |
| SCHEMBL18954525 | 0.75 | HTT (0.60) | LMNATSHRPOLBMEN1KMT2A | |
| SCHEMBL18973386 | 0.74 | NPSR1 (0.46) | NPSR1CYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL18973480 | 0.72 | HTT (0.51) | NPSR1CYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL16444364 | 0.72 | TSHR (0.75) | NPSR1CYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL14825379 | 0.70 | LMNA (0.52) | LMNATSHRPOLBMEN1KMT2A | |
| SCHEMBL18954516 | 0.70 | POLB (0.71) | NPSR1CYP1A2CYP3A4CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219507-A2 | THIENOPYRIMIDINONE NMDA RECEPTOR MODULATORS AND USES THEREOF | Novartis AG (CH) | 2023-08-02 | — | — | EP | disclosed |