Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 18/20 | 0.75 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.75 |
| ▸ | FLT3 | P36888 | 5/20 | 0.75 |
| ▸ | KIT | P10721 | 3/20 | 0.75 |
| ▸ | LCK | P06239 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.75 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25909903 | 0.91 | CSF1R (0.72) | CSF1RPDGFRAPDGFRBFLT3KIT | |
| SCHEMBL25909794 | 0.89 | CSF1R (0.75) | CSF1RPDGFRAPDGFRBFLT3KIT | |
| SCHEMBL25909908 | 0.88 | CSF1R (0.79) | CSF1RPDGFRAPDGFRBFLT3KIT | |
| SCHEMBL25910024 | 0.88 | CSF1R (0.74) | CSF1RPDGFRAPDGFRBFLT3KIT | |
| Vimseltinib SCHEMBL30453793 | 0.86 | CSF1R (1.00) | CSF1RPDGFRAPDGFRBFLT3KIT | |
| Vimseltinib SCHEMBL16047448 | 0.86 | CSF1R (1.00) | CSF1RPDGFRAPDGFRBFLT3KIT | |
| Vimseltinib SCHEMBL31615255 | 0.85 | CSF1R (0.98) | CSF1RPDGFRAPDGFRBFLT3KIT | |
| SCHEMBL25911604 | 0.85 | CSF1R (0.53) | CSF1RPDGFRAPDGFRBFLT3KIT | |
| SCHEMBL25910156 | 0.85 | CSF1R (0.74) | CSF1RPDGFRAPDGFRBFLT3KIT | |
| SCHEMBL25909923 | 0.84 | CSF1R (0.76) | CSF1RPDGFRAPDGFRBFLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125812-A1 | SUBSTITUTED PYRIMIDONE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND MEDICAL USE THEREOF | 上海海雁医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |