Sugi Predict

Sugi Predict / Compounds / Propylparaben

Propylparaben

Propylparaben

SCHEMBL2591109

CCCOC(=O)c1ccc(O)cc1.NC(=O)NN1CCNC1

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.56
▸ ESR1 P03372 3/20 0.56
▸ TSHR P16473 3/20 0.56
▸ CHRM1 P11229 1/20 0.56
▸ SLC6A2 P23975 1/20 0.56
▸ KDR P35968 1/20 0.56
▸ TDP1 Q9NUW8 1/20 0.56
▸ LMNA P02545 4/20 0.47
▸ SMN1; SMN2 Q16637 3/20 0.47
▸ CYP2D6 P10635 2/20 0.47
▸ CYP1A2 P05177 2/20 0.47
▸ CYP2C19 P33261 2/20 0.47
▸ MAPK1 P28482 2/20 0.47
▸ NR1H2 P55055 1/20 0.47
▸ RNASEL Q05823 1/20 0.47
▸ MEN1 O00255 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ CA12 O43570 1/20 0.42
▸ CA1 P00915 1/20 0.42
▸ CA2 P00918 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propylparaben SCHEMBL27678040 0.97 ESR1 (0.52) ALDH1A1ESR1TSHRCHRM1SLC6A2
Methylparaben SCHEMBL2859805 0.86 CA1 (0.51) ALDH1A1TDP1LMNASMN1; SMN2CA12
Methylparaben SCHEMBL4757750 0.85 CA1 (0.50) ALDH1A1TDP1LMNASMN1; SMN2CA12
Propylparaben SCHEMBL3829476 0.80 ESR1 (0.52) ALDH1A1ESR1TSHRCHRM1SLC6A2
Paraben SCHEMBL2591112 0.80 CA2 (0.44) TSHRLMNAMEN1KMT2ACA12
Propylparaben SCHEMBL5706447 0.76 ESR1 (0.89) ALDH1A1ESR1TSHRCHRM1SLC6A2
Propylparaben SCHEMBL31538674 0.76 ESR1 (0.96) ALDH1A1ESR1TSHRCHRM1SLC6A2
Propylparaben SCHEMBL29379762 0.76 ESR1 (0.96) ALDH1A1ESR1TSHRCHRM1SLC6A2
Propylparaben SCHEMBL977 0.74 ESR1 (1.00) ALDH1A1ESR1TSHRCHRM1SLC6A2
Propylparaben SCHEMBL429594 0.74 ESR1 (1.00) ALDH1A1ESR1TSHRCHRM1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6582710-B2 Washed oil bodies and surfactants, emollients, fragrances, preservatives, antioxidants, emulsion stabilizing agents, moisturizers; sunscreen agents, anti-wrinkling agents, antiacne, antipsoriasis agents SEMBIOSYS GENETICS INC. (CA) 2003-06-24 — — US claimed
EP-3125880-B1 COMBINATION OF ADAPALENE AND BENZOYL PEROXIDE FOR PREVENTING ACNE SCARS GALDERMA RES & DEV (FR) 2019-11-20 — — EP disclosed
EP-2563357-B1 ADAPALENE 0.3% FOR USE IN A METHOD FOR TREATING SCARS GALDERMA RES & DEV (FR) 2018-10-17 — — EP disclosed
US-20180214401-A1 METHOD FOR TREATING SCARS WITH ADAPALENE 0.3% GALDERMA RESEARCH & DEVELOPMENT (FR) 2018-08-02 — — US disclosed
EP-3125880-A1 COMBINATION OF ADAPALENE AND BENZOYL PEROXIDE FOR TREATING ACNE SCARS Galderma Research & Development (FR) 2017-02-08 — — EP disclosed
US-20170020833-A1 METHOD FOR TREATING AND/OR PREVENTING ACNE SCARS WITH A FIXED COMBINATION OF ADAPALENE OR ITS SALTS AND BENZOYL PEROXIDE GALDERMA RESEARCH & DEVELOPMENT (FR) 2017-01-26 — — US disclosed
WO-2015150332-A1 COMBINATION OF ADAPALENE AND BENZOYL PEROXIDE FOR TREATING ACNE SCARS GALDERMA RESEARCH & DEVELOPMENT (FR) 2015-10-08 — — WO disclosed
US-20130203850-A1 METHOD FOR TREATING SCARS WITH ADAPALENE 0.3% GALDERMA RESEARCH & DEVELOPMENT (FR) 2013-08-08 — — US disclosed
EP-2563357-A1 METHOD FOR TREATING SCARS WITH ADAPALENE 0.3% Galderma Research & Development (FR) 2013-03-06 — — EP disclosed
WO-2011135090-A1 METHOD FOR TREATING SCARS WITH ADAPALENE 0.3% GALDERMA RESEARCH & DEVELOPMENT (FR) 2011-11-03 — — WO disclosed