Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 8/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | HAMP | P81172 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.31 |
| ▸ | BTK | Q06187 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25326488 | 0.87 | PRMT5 (0.37) | PRMT5FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL25324452 | 0.79 | PRMT5 (0.37) | PRMT5WDR77PIM2TTK | |
| SCHEMBL25326770 | 0.78 | PRMT5 (0.35) | PRMT5WDR77PIM2ROCK2CYP3A4 | |
| SCHEMBL25329073 | 0.74 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL25325556 | 0.74 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL25326154 | 0.74 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL25327462 | 0.73 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL25327240 | 0.72 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL25327238 | 0.72 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL30522970 | 0.72 | PRMT5 (0.37) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146991-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |