Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | PAM | P19021 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL27437981 | 0.76 | CES1 (0.54) | CES1CES2AKR1B1HIF1AKMT2A | |
| SCHEMBL25169 | 0.74 | CES1 (0.58) | CES1CES2AKR1B1PAMKMT2A | |
| SCHEMBL4712969 | 0.74 | AKR1B1 (0.52) | CES1CES2AKR1B1HIF1APAM | |
| SCHEMBL25676 | 0.73 | CES1 (0.64) | CES1CES2AKR1B1HIF1AKMT2A | |
| Bicarbonate SCHEMBL10938525 | 0.73 | CES1 (0.56) | CES1CES2AKR1B1PAMKMT2A | |
| SCHEMBL3485127 | 0.73 | CES1 (0.50) | CES1CES2AKR1B1PAMKMT2A | |
| SCHEMBL16653799 | 0.73 | CES1 (0.50) | CES1CES2AKR1B1PAMKMT2A | |
| SCHEMBL28067062 | 0.72 | CES1 (0.45) | CES1CES2AKR1B1PAMKMT2A | |
| SCHEMBL28085046 | 0.72 | CES1 (0.55) | CES1CES2AKR1B1HIF1AKMT2A | |
| SCHEMBL5184996 | 0.72 | CES1 (0.55) | CES1CES2AKR1B1HIF1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105820252-A | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases | ATYR 医药公司 | 2016-08-03 | — | — | CN | claimed |
| CN-103096912-A | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases | ATYR PHARMA INC | 2013-05-08 | — | — | CN | claimed |
| EP-2566495-A2 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-ALPHA-TRNA SYNTHETASES | aTyr Pharma, Inc. (US) | 2013-03-13 | — | — | EP | claimed |
| WO-2011140132-A2 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-ALPHA-TRNA SYNTHETASES | ATYR PHARMA, INC. (US) | 2011-11-10 | — | — | WO | claimed |
| US-10179906-B2 | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases | ATYR PHARMA, INC. (US) | 2019-01-15 | — | — | US | disclosed |
| US-20170247678-A1 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-ALPHA-tRNA SYNTHETASES | ATYR PHARMA, INC. | 2017-08-31 | — | — | US | disclosed |
| US-9593323-B2 | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases | ATYR PHARMA, INC. (US) | 2017-03-14 | — | — | US | disclosed |
| EP-2566495-B1 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-ALPHA-TRNA SYNTHETASES | ATYR PHARMA INC (US) | 2017-03-01 | — | — | EP | disclosed |
| CN-105820252-A | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases | ATYR 医药公司 | 2016-08-03 | — | — | CN | disclosed |
| US-20150361410-A1 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-ALPHA-TRNA SYNTHETASES | PANGU BIOPHARMA LIMITED (HK) | 2015-12-17 | — | — | US | disclosed |
| US-9034321-B2 | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases | ATYR PHARMA, INC. (US) | 2015-05-19 | — | — | US | disclosed |
| US-20130195832-A1 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-ALPHA-TRNA SYNTHETASES | PANGU BIOPHARMA LIMITED (CN) | 2013-08-01 | — | — | US | disclosed |
| CN-103096912-A | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases | ATYR PHARMA INC | 2013-05-08 | — | — | CN | disclosed |
| EP-2566495-A2 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-ALPHA-TRNA SYNTHETASES | aTyr Pharma, Inc. (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140132-A2 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-ALPHA-TRNA SYNTHETASES | ATYR PHARMA, INC. (US) | 2011-11-10 | — | — | WO | disclosed |