SCHEMBL25914488

SCHEMBL25914488

CCc1ccc(C(N)=O)cc1F

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 3/20 0.46
MAPK1 P28482 1/20 0.44
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
SLC6A3 Q01959 1/20 0.43
PARP10 Q53GL7 2/20 0.43
MAOB P27338 2/20 0.41
PARP15 Q460N3 1/20 0.41
PARP14 Q460N5 1/20 0.41
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
HTR1A P08908 2/20 0.41
HTR1D P28221 2/20 0.41
HTR2C P28335 2/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
TSHR P16473 1/20 0.41
HTR1B P28222 1/20 0.41
HTR7 P34969 1/20 0.41
HTR5A P47898 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1696329 1.00 PARP1 (0.46) PARP1MAPK1SLC6A2SLC6A4SLC6A3
SCHEMBL25017930 0.87 PARP10 (0.43) PARP1MAPK1SLC6A2SLC6A4SLC6A3
SCHEMBL30474148 0.85 PARP1 (0.46) PARP1SLC6A2SLC6A4SLC6A3PARP10
SCHEMBL3688309 0.85 PARP1 (0.46) PARP1MAPK1SLC6A2SLC6A4SLC6A3
SCHEMBL31279141 0.85 PARP1 (0.46) PARP1MAPK1SLC6A2SLC6A4SLC6A3
SCHEMBL12831932 0.84 RXRA (0.40) PARP1MAPK1SLC6A2SLC6A4SLC6A3
SCHEMBL17315543 0.83 HTR2C (0.54) PARP1SLC6A2PARP10MAOBPARP15
SCHEMBL21552048 0.83 PARP1 (0.44) PARP1SLC6A2SLC6A4SLC6A3PARP10
SCHEMBL20300366 0.83 PARP1 (0.44) PARP1SLC6A2SLC6A4SLC6A3PARP10
SCHEMBL18977485 0.83 PRSS1 (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023144736-A1 COMPOSITIONS FOR PREVENTING OR TREATING PULMONARY ARTERIAL HYPERTENSION CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2023-08-03 WO disclosed
WO-2023144737-A1 COMPOSITIONS FOR PREVENTING OR TREATING HEART FAILURE (HF) CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2023-08-03 WO disclosed