Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 5/20 | 0.35 |
| ▸ | HTR2C | P28335 | 5/20 | 0.35 |
| ▸ | HTR2B | P41595 | 5/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23997233 | 0.86 | ALDH1A1 (0.43) | MKNK2MKNK1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL29978011 | 0.77 | ALDH1A1 (0.47) | MKNK2MKNK1ALDH1A1NPC1LMNA | |
| SCHEMBL28387305 | 0.77 | ALDH1A1 (0.47) | MKNK2MKNK1ALDH1A1NPC1LMNA | |
| SCHEMBL25317459 | 0.77 | MKNK2 (0.47) | MKNK2MKNK1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL11188454 | 0.75 | CYP1A2 (0.46) | SMN1; SMN2ALDH1A1NPC1LMNAMAPT | |
| SCHEMBL14991575 | 0.75 | MKNK2 (0.46) | MKNK2MKNK1MAPTMEN1KMT2A | |
| SCHEMBL20529362 | 0.75 | MKNK2 (0.46) | MKNK2MKNK1MAPTHTR2AHTR2C | |
| SCHEMBL18786964 | 0.75 | MKNK2 (0.46) | MKNK2MKNK1KMT2A | |
| SCHEMBL13756884 | 0.74 | HTR2A (0.62) | HTR2AHTR2CHTR2B | |
| SCHEMBL8157312 | 0.73 | CNR1 (0.43) | MKNK2MKNK1SMN1; SMN2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139379-A1 | MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE (ROCK) | REDX PHARMA PLC (GB) | 2023-07-27 | — | — | WO | disclosed |