SCHEMBL25916095

SCHEMBL25916095

CC(C)[C@H](N)C(=O)O[C@H]1[C@@H](O)C[C@](C#N)(c2ccc3c(N)ncnn23)O[C@@H]1COC(=O)Cc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ RIPK1 Q13546 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25916612 0.91 TMPRSS2 (0.31) —
SCHEMBL25915389 0.90 TMPRSS2 (0.30) —
SCHEMBL25916196 0.90 TMPRSS2 (0.31) —
SCHEMBL25916424 0.90 TMPRSS2 (0.31) —
SCHEMBL24916816 0.88 TMPRSS2 (0.37) RIPK1
SCHEMBL25915463 0.87 — —
SCHEMBL30090966 0.86 TMPRSS2 (0.34) RIPK1
SCHEMBL25922826 0.86 TMPRSS2 (0.34) RIPK1
SCHEMBL24790458 0.86 TMPRSS2 (0.34) RIPK1
SCHEMBL24916817 0.85 RIPK1 (0.32) RIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230233593-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS VenatoRx Pharmaceuticals, Inc. 2023-07-27 — — US disclosed
US-11638715-B2 Orally-bioavailable nucleoside analogs VenatoRx Pharmaceuticals, Inc. (US) 2023-05-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11638715-B2 Orally-bioavailable nucleoside analogs SLC29A2, SLC29A1, PNP RIPK1 2571/4885
US-20230233593-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS SLC29A2, SLC29A1, PNP RIPK1 2571/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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