Sugi Predict

Sugi Predict / Compounds / SCHEMBL259192

SCHEMBL259192

SCHEMBL259192

COc1ccc(C(=O)Nc2c(C(=O)O)oc3ncccc23)cc1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.56
▸ TP53 P04637 5/20 0.56
▸ RXFP1 Q9HBX9 3/20 0.52
▸ F2 P00734 1/20 0.51
▸ RAB9A P51151 4/20 0.48
▸ LMNA P02545 1/20 0.48
▸ NPC1 O15118 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ ADORA3 P0DMS8 1/20 0.46
▸ GPR35 Q9HC97 1/20 0.46
▸ PPARG P37231 1/20 0.46
▸ NCOR2 Q9Y618 1/20 0.46
▸ POLB P06746 2/20 0.46
▸ ALDH1A1 P00352 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13298528 0.90 MAPT (0.56) MAPTTP53RXFP1F2RAB9A
SCHEMBL259253 0.88 MEN1 (0.57) MAPTTP53RXFP1RAB9ALMNA
SCHEMBL259335 0.87 ALDH1A1 (0.53) MAPTTP53RXFP1F2RAB9A
SCHEMBL259251 0.86 KDM4E (0.58) MAPTTP53RXFP1F2LMNA
SCHEMBL259344 0.81 KDR (0.50) MAPTTP53RAB9ALMNANPC1
SCHEMBL259353 0.78 MEN1 (0.70) MAPTTP53RXFP1RAB9ALMNA
SCHEMBL259376 0.77 ALDH1A1 (0.41) MAPTTP53KMT2APOLBALDH1A1
SCHEMBL259348 0.77 ALDH1A1 (0.66) MAPTTP53RXFP1RAB9ALMNA
SCHEMBL14581998 0.76 HTT (0.57) MAPTRAB9ALMNANPC1KMT2A
SCHEMBL3728067 0.76 KDR (0.47) MAPTRAB9ALMNANPC1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8067586-B2 Fused heteroaryl derivatives ASTELLAS PHARMA INC. (JP) 2011-11-29 — — US disclosed
US-8067586-B2 Fused heteroaryl derivatives ASTELLAS PHARMA INC. (JP) 2011-11-29 — — US disclosed
US-20100137584-A1 FUSED HETEROARYL DERIVATIVES HAYAKAWA MASAHIKO 2010-06-03 — — US disclosed
US-20100137584-A1 FUSED HETEROARYL DERIVATIVES HAYAKAWA MASAHIKO 2010-06-03 — — US disclosed
US-20100137585-A1 FUSED HETEROARYL DERIVATIVES HAYAKAWA MASAHIKO 2010-06-03 — — US disclosed
US-20100137585-A1 FUSED HETEROARYL DERIVATIVES HAYAKAWA MASAHIKO 2010-06-03 — — US disclosed
US-20070037805-A1 Fused heteroaryl derivatives HAYAKAWA MASAHIKO 2007-02-15 — — US disclosed
US-20070037805-A1 Fused heteroaryl derivatives HAYAKAWA MASAHIKO 2007-02-15 — — US disclosed
US-7173029-B2 Fused heteroaryl derivatives ASTELLAS PHARMA INC. (JP) 2007-02-06 — — US disclosed
US-7173029-B2 Fused heteroaryl derivatives ASTELLAS PHARMA INC. (JP) 2007-02-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137584-A1 FUSED HETEROARYL DERIVATIVES PIK3CD, PIK3R3, PIK3C2A MAPT 3923/4885TP53 92/4885RXFP1 4866/4885
US-20070037805-A1 Fused heteroaryl derivatives PIK3CD, PIK3R3, PIK3C2A MAPT 3923/4885TP53 92/4885RXFP1 4866/4885
US-20100137585-A1 FUSED HETEROARYL DERIVATIVES PIK3CD, PIK3R3, PIK3C2A MAPT 3923/4885TP53 92/4885RXFP1 4866/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.