Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 13/20 | 0.85 |
| ▸ | RAF1 | P04049 | 5/20 | 0.85 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.85 |
| ▸ | SRC | P12931 | 7/20 | 0.73 |
| ▸ | WEE2 | P0C1S8 | 2/20 | 0.70 |
| ▸ | WEE1 | P30291 | 2/20 | 0.70 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.70 |
| ▸ | ABL1 | P00519 | 2/20 | 0.68 |
| ▸ | EGFR | P00533 | 2/20 | 0.68 |
| ▸ | SYK | P43405 | 2/20 | 0.68 |
| ▸ | FLT1 | P17948 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
| ▸ | FYN | P06241 | 2/20 | 0.68 |
| ▸ | STK25 | O00506 | 1/20 | 0.67 |
| ▸ | CIT | O14578 | 1/20 | 0.67 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.67 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.67 |
| ▸ | CASK | O14936 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31748812 | 0.94 | MAP2K1 (0.75) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL346145 | 0.92 | MAP2K1 (1.00) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL25920207 | 0.92 | MAP2K1 (0.83) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL25920314 | 0.90 | SRC (0.80) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL4956978 | 0.89 | MAP2K1 (0.75) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL25920410 | 0.89 | MAP2K1 (0.68) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL25920361 | 0.88 | SRC (0.80) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL25920191 | 0.87 | MAP2K1 (0.84) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL25920940 | 0.87 | MAP2K1 (0.72) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL4954018 | 0.87 | MAP2K1 (0.72) | MAP2K1RAF1MAPK3MAPK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141635-A2 | HER3 LIGANDS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-07-27 | — | — | WO | disclosed |