Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 15/20 | 0.72 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25922296 | 0.93 | YAP1 (0.74) | YAP1ITGB3ITGA2B | |
| SCHEMBL21359046 | 0.93 | YAP1 (0.74) | YAP1ITGB3ITGA2B | |
| SCHEMBL21366139 | 0.93 | YAP1 (0.74) | YAP1ITGB3ITGA2B | |
| SCHEMBL25922288 | 0.92 | YAP1 (0.70) | YAP1ITGB3ITGA2B | |
| SCHEMBL25922291 | 0.92 | YAP1 (0.72) | YAP1ITGB3ITGA2B | |
| SCHEMBL25922281 | 0.89 | YAP1 (0.72) | YAP1ITGB3ITGA2B | |
| SCHEMBL23296248 | 0.88 | YAP1 (0.92) | YAP1 | |
| SCHEMBL19974535 | 0.88 | YAP1 (0.92) | YAP1 | |
| SCHEMBL25922285 | 0.87 | YAP1 (0.70) | YAP1ITGB3ITGA2B | |
| SCHEMBL25754091 | 0.87 | YAP1 (0.84) | YAP1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234924-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234924-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | YAP1, YES1, MYC | YAP1 1/4885ITGB3 4602/4885ITGA2B 4535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.