Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 19/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25321064 | 1.00 | PRMT5 (0.44) | PRMT5WDR77KDM4ENSD2ALDH1A1 | |
| SCHEMBL25322442 | 1.00 | PRMT5 (0.44) | PRMT5WDR77KDM4ENSD2ALDH1A1 | |
| SCHEMBL25322395 | 0.91 | PRMT5 (0.44) | PRMT5WDR77KDM4E | |
| SCHEMBL30886341 | 0.90 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL25321558 | 0.88 | SCD5 (0.42) | PRMT5WDR77KDM4ENSD2ALDH1A1 | |
| SCHEMBL30886237 | 0.87 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL25321003 | 0.87 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL25321001 | 0.87 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL30551215 | 0.86 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL25920494 | 0.86 | PRMT5 (0.43) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |