Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.57 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | F11 | P03951 | 3/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12185974 | 0.84 | BACE1 (0.49) | USP30AAK1BACE1BACE2CA1 | |
| SCHEMBL484122 | 0.83 | AAK1 (0.45) | USP30AAK1BACE1BACE2CA1 | |
| SCHEMBL18204544 | 0.82 | BACE1 (0.45) | USP30AAK1BACE1BACE2CA1 | |
| SCHEMBL1019640 | 0.81 | BACE1 (0.45) | USP30AAK1BACE1BACE2CA1 | |
| SCHEMBL25142321 | 0.80 | AAK1 (0.47) | USP30AAK1BACE1BACE2CA1 | |
| SCHEMBL2565930 | 0.80 | AAK1 (0.47) | USP30AAK1BACE1BACE2CA1 | |
| SCHEMBL29840307 | 0.80 | AAK1 (0.47) | USP30AAK1BACE1BACE2CA1 | |
| SCHEMBL2565928 | 0.80 | AAK1 (0.47) | USP30AAK1BACE1BACE2CA1 | |
| SCHEMBL2595119 | 0.80 | AAK1 (0.45) | USP30AAK1BACE1BACE2CA1 | |
| SCHEMBL23753406 | 0.80 | LIPG (0.47) | USP30AAK1BACE1BACE2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123419-A1 | TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2011-10-06 | — | — | WO | disclosed |