Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 7/20 | 0.42 |
| ▸ | KDM4A | O75164 | 7/20 | 0.42 |
| ▸ | KDM4D | Q6B0I6 | 7/20 | 0.42 |
| ▸ | HIF1AN | Q9NWT6 | 7/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 7/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.42 |
| ▸ | KDM3B | Q7LBC6 | 6/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339112 | 0.82 | MAPT (0.49) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL9337517 | 0.80 | KDM4E (0.45) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL4433471 | 0.80 | KDM4E (0.45) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL11372438 | 0.80 | BRS3 (0.43) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL3912930 | 0.77 | KDM4E (0.53) | KDM4ESMN1; SMN2KDM6BKDM4AKDM4D | |
| SCHEMBL10757493 | 0.77 | KDM4E (0.45) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL25148577 | 0.76 | KDM4E (0.66) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL4428193 | 0.75 | DAO (0.54) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL7016645 | 0.75 | KDM4E (0.41) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL4428237 | 0.74 | KDM4E (0.50) | KDM4EKDM6BKDM4AKDM4DHIF1AN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595989-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2013067248-A1 | BENZOXAZINES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-05-10 | — | — | WO | disclosed |
| WO-2011140425-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-10 | — | — | WO | disclosed |