Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | KDM4A | O75164 | 5/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.49 |
| ▸ | KDM6B | O15054 | 4/20 | 0.49 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.49 |
| ▸ | HIF1AN | Q9NWT6 | 4/20 | 0.49 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.49 |
| ▸ | KDM3B | Q7LBC6 | 3/20 | 0.48 |
| ▸ | KDM5A | P29375 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | BRS3 | P32247 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428237 | 0.97 | KDM4E (0.50) | KDM4EKDM4AKDM5BKDM6BKDM4D | |
| SCHEMBL4432424 | 0.92 | HNF4A (0.49) | KDM4EKDM4AKDM5BKDM6BKDM4D | |
| SCHEMBL4432530 | 0.91 | KDM4E (0.47) | KDM4EKDM4AKDM5BKDM6BKDM4D | |
| SCHEMBL4433258 | 0.91 | KDM4E (0.55) | KDM4EKDM4AKDM5BKDM6BKDM4D | |
| SCHEMBL11836193 | 0.87 | KDM4E (0.42) | KDM4EKDM4AKDM5BKDM6BKDM4D | |
| SCHEMBL4430692 | 0.87 | KDM4E (0.51) | KDM4EKDM4AKDM5BKDM6BKDM4D | |
| SCHEMBL3917621 | 0.85 | DAO (0.46) | KDM4EKDM4AKDM5BKDM6BKDM4D | |
| SCHEMBL4430485 | 0.85 | KDM4E (0.41) | KDM4EKDM4AKDM5BKDM6BKDM4D | |
| SCHEMBL3920671 | 0.85 | DAO (0.54) | KDM4EKDM4AKDM5BKDM4CDAO | |
| SCHEMBL4428193 | 0.85 | DAO (0.54) | KDM4EKDM4AKDM5BKDM6BKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | Incyte Corporation (US) | 2019-02-06 | — | — | EP | disclosed |
| WO-2017172596-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION (US) | 2017-10-05 | — | — | WO | disclosed |
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| EP-2032538-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
| WO-2007146824-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| US-3948903-A | Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -cephaloglycins | PARKE, DAVIS & COMPANY (US) | 1976-04-06 | — | — | US | disclosed |