Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Alanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 4/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alanine SCHEMBL2592625 | 1.00 | SLC7A5 (0.48) | SLC7A5TP53PMP22GRM5GRM1 | |
| Alanine SCHEMBL27873237 | 1.00 | SLC7A5 (0.48) | SLC7A5TP53PMP22GRM5GRM1 | |
| Alanine SCHEMBL31150674 | 1.00 | SLC7A5 (0.48) | SLC7A5TP53PMP22GRM5GRM1 | |
| Alanine SCHEMBL27282765 | 0.97 | SLC7A5 (0.46) | SLC7A5TP53PMP22GRM5GRM1 | |
| Alanine SCHEMBL28212270 | 0.91 | CA1 (0.47) | SLC7A5TP53PMP22GRM5GRM1 | |
| Alanine SCHEMBL17874434 | 0.91 | SLC7A5 (0.46) | SLC7A5TP53PMP22GRM5GRM1 | |
| Alanine SCHEMBL17874433 | 0.91 | SLC7A5 (0.46) | SLC7A5TP53PMP22GRM5GRM1 | |
| Alanine SCHEMBL27547955 | 0.89 | SLC7A5 (0.40) | SLC7A5TP53PMP22GRM5GRM1 | |
| Alanine SCHEMBL27620225 | 0.88 | SLC7A5 (0.43) | SLC7A5TP53PMP22GRM5GRM1 | |
| Alanine SCHEMBL27620224 | 0.88 | SLC7A5 (0.43) | SLC7A5TP53PMP22GRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111406216-A | Compounds, reagents and uses thereof | 麦特博隆股份有限公司 | 2020-07-10 | — | — | CN | disclosed |
| CN-102698808-B | The purposes of a kind of composite catalyst and clean catalytic oxidization cyclohexene synthesizing adipic acid thereof | BEIJING XUYANG CHEMICAL TECHNOLOGY RESEARCH INSTITUTE CO., LTD. (CN) | 2015-07-29 | — | — | CN | disclosed |
| CN-103852439-A | Volatile organic compound monitoring equipment and method | BEIJING SDL TECHNOLOGY CO LTD | 2014-06-11 | — | — | CN | disclosed |
| EP-2566367-A1 | TOOTHBRUSH | The Gillette Company (US) | 2013-03-13 | — | — | EP | disclosed |
| CN-102828284-A | Method for preparing high-strength chitosan fiber with binary solvent system | UNIV DONGHUA | 2012-12-19 | — | — | CN | disclosed |
| WO-2011140346-A1 | TOOTHBRUSH | THE GILLETTE COMPANY (US) | 2011-11-10 | — | — | WO | disclosed |
| EP-1159612-B1 | INTEGRATED ASSAY FOR ORGAN FUNCTION, DRUGS AND/OR METABOLITES | LIFESCAN INC (US) | 2006-12-13 | — | — | EP | disclosed |
| CN-1151887-C | L-hydrosulformidate type chiral ionic liquid and its prepn | 华东师范大学 | 2004-06-02 | — | — | CN | disclosed |
| CN-1150994-C | L-sulforamidate type chiral ionic liquid and its prepn | 华东师范大学 | 2004-05-26 | — | — | CN | disclosed |
| US-20040018628-A1 | Integrated assay for organ function, drug and / or one or more metabolites | LXN CORPORATION | 2004-01-29 | — | — | US | disclosed |
| US-6627153-B1 | Strips and instrument for rapid, easy in home or office monitoring of multiple medical aspects | JOHNSON & JOHNSON CONSUMER INC. | 2003-09-30 | — | — | US | disclosed |
| CN-1383921-A | L-hydrosulformidate type chiral ionic liquid and its prepn | UNIV HUADONG (CN) | 2002-12-11 | — | — | CN | disclosed |
| CN-1383920-A | L-sulforamidate type chiral ionic liquid and its prepn | UNIV HUADONG (CN) | 2002-12-11 | — | — | CN | disclosed |