Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14972719 | 0.85 | EPHX2 (0.38) | ATM | |
| SCHEMBL3492775 | 0.84 | GPR119 (0.43) | GPR119CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL3492773 | 0.84 | GPR119 (0.43) | GPR119CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL2590439 | 0.83 | GPR119 (0.42) | GPR119CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL2596043 | 0.82 | GPR119 (0.41) | GPR119CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL2591066 | 0.80 | TSHR (0.44) | GPR119CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL2592446 | 0.79 | GPR119 (0.38) | GPR119CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL21397530 | 0.76 | HDAC3 (0.45) | GPR119CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL10258300 | 0.75 | ATM (0.43) | GPR119ATM | |
| SCHEMBL3702583 | 0.75 | ATM (0.56) | GPR119ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595989-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2011140425-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-10 | — | — | WO | disclosed |