Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.38 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL8582773 | 0.92 | TLR2 (0.34) | TLR2DPP7 | |
| Threonine SCHEMBL26979733 | 0.91 | QARS1 (0.33) | GRM8GRM6GRIN2DGRIN3BGSR | |
| D-Glutamate SCHEMBL27639981 | 0.89 | GRM8 (0.44) | GRM8GRM6GRIN2DGRIN3BGSR | |
| Glutamic Acid SCHEMBL7654784 | 0.89 | GRM8 (0.44) | GRM8GRM6GRIN2DGRIN3BGSR | |
| D-Glutamate SCHEMBL27779763 | 0.85 | GRM8 (0.40) | GRM8GRM6GRIN2DGRIN3BGSR | |
| Glutamic Acid SCHEMBL8852502 | 0.84 | CYP1A2 (0.49) | GRM8GRM6GRIN2DGRIN3BGSR | |
| D-Glutamate SCHEMBL29255769 | 0.84 | CYP1A2 (0.49) | GRM8GRM6GRIN2DGRIN3BGSR | |
| D-Glutamate SCHEMBL2201557 | 0.84 | GRM8 (0.55) | GRM8GRM6GRIN2DGRIN3BGSR | |
| Glutamic Acid SCHEMBL515160 | 0.84 | GRM8 (0.55) | GRM8GRM6GRIN2DGRIN3BGSR | |
| Glutamic Acid SCHEMBL16290410 | 0.84 | GRM8 (0.55) | GRM8GRM6GRIN2DGRIN3BGSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011140295-A2 | MODULATORS OF NOTCH RECEPTOR SIGNALING AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-11-10 | — | — | WO | disclosed |