Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | TDP2 | O95551 | 2/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592975 | 0.90 | SYK (0.41) | SYKADORA1CD274TDP2ERN1 | |
| SCHEMBL2593326 | 0.84 | ADORA1 (0.39) | ADORA1TDP2ERN1SCN9A | |
| SCHEMBL2592836 | 0.84 | GSK3B (0.40) | ADORA1TDP2 | |
| SCHEMBL2592364 | 0.80 | PRF1 (0.46) | — | |
| SCHEMBL2591435 | 0.76 | GSK3B (0.42) | ADORA1TDP2 | |
| SCHEMBL2584273 | 0.74 | MAPKAPK2 (0.39) | ADORA1TDP2 | |
| SCHEMBL2591933 | 0.73 | HSD17B1 (0.48) | ADORA1 | |
| SCHEMBL2592599 | 0.72 | HSD17B1 (0.45) | ADORA1ERN1 | |
| SCHEMBL2589787 | 0.71 | PRF1 (0.48) | — | |
| SCHEMBL2593036 | 0.71 | PRF1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | claimed |
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | claimed |
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |