Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5951526 | 0.94 | TDP1 (0.51) | TDP1ALDH1A1TSHRHSP90AA1CDK5 | |
| SCHEMBL10713235 | 0.86 | TDP1 (0.58) | TDP1ALDH1A1TSHRHSP90AA1CDK5 | |
| SCHEMBL7657590 | 0.86 | TDP1 (0.58) | TDP1ALDH1A1TSHRHSP90AA1CDK5 | |
| SCHEMBL10535570 | 0.82 | TDP1 (0.53) | TDP1ALDH1A1TSHRHSP90AA1CDK5 | |
| SCHEMBL6571872 | 0.81 | ALDH1A1 (0.51) | TDP1ALDH1A1TSHRHSP90AA1CDK5 | |
| SCHEMBL15940087 | 0.81 | ALDH1A1 (0.51) | TDP1ALDH1A1TSHRMEN1MAPT | |
| SCHEMBL7653302 | 0.80 | TDP1 (0.50) | TDP1ALDH1A1TSHRHSP90AA1CDK5 | |
| SCHEMBL28021831 | 0.78 | ALDH1A1 (0.56) | TDP1ALDH1A1TSHRMEN1MAPT | |
| SCHEMBL10589548 | 0.77 | ALDH1A1 (0.51) | TDP1ALDH1A1TSHRMEN1MAPT | |
| SCHEMBL30532395 | 0.77 | ALDH1A1 (0.51) | TDP1ALDH1A1TSHRMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242512-A1 | ISOINDOLINES AS HDAC INHIBITORS | VALO HEALTH, INC. | 2023-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242512-A1 | ISOINDOLINES AS HDAC INHIBITORS | HDAC1, HDAC2, HDAC3 | TDP1 889/4885ALDH1A1 1133/4885TSHR 3102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.