Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.84 |
| ▸ | RECQL | P46063 | 2/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.84 |
| ▸ | RAB9A | P51151 | 2/20 | 0.84 |
| ▸ | BLM | P54132 | 2/20 | 0.84 |
| ▸ | POLB | P06746 | 1/20 | 0.84 |
| ▸ | MAPT | P10636 | 1/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | GLA | P06280 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.65 |
| ▸ | ACHE | P22303 | 1/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.65 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 9-Aminocamptothecin SCHEMBL29369669 | 0.92 | TOP1 (1.00) | TOP1KDM4ERECQLTDP1RAB9A | |
| Rs-9-Aminocamptothecin SCHEMBL8715088 | 0.92 | TOP1 (1.00) | TOP1KDM4ERECQLTDP1RAB9A | |
| 9-Aminocamptothecin SCHEMBL26578 | 0.92 | TOP1 (1.00) | TOP1KDM4ERECQLTDP1RAB9A | |
| SCHEMBL25932513 | 0.89 | TOP1 (0.85) | TOP1KDM4ERECQLTDP1RAB9A | |
| Rs-9-Aminocamptothecin SCHEMBL27705522 | 0.88 | TOP1 (0.92) | TOP1KDM4ERECQLTDP1RAB9A | |
| SCHEMBL25932527 | 0.87 | ABCC4 (0.85) | TOP1KDM4ERECQLTDP1RAB9A | |
| SCHEMBL17897672 | 0.87 | TOP1 (0.72) | TOP1KDM4ERECQLTDP1RAB9A | |
| SCHEMBL14065448 | 0.87 | TOP1 (0.83) | TOP1KDM4ERECQLTDP1RAB9A | |
| SCHEMBL10298065 | 0.87 | TOP1 (0.83) | TOP1KDM4ERECQLTDP1RAB9A | |
| SCHEMBL25932533 | 0.86 | TOP1 (0.86) | TOP1KDM4ERECQLTDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230241241-A1 | CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230241241-A1 | CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS | CD4, DCLRE1A, TOP1 | TOP1 3/4885KDM4E 4137/4885RECQL 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.