Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rs-9-Aminocamptothecin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 known ✓ | P11387 | 18/20 | 0.92 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.92 |
| ▸ | RAB9A | P51151 | 2/20 | 0.92 |
| ▸ | BLM | P54132 | 2/20 | 0.92 |
| ▸ | RECQL | P46063 | 2/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.92 |
| ▸ | POLB | P06746 | 1/20 | 0.92 |
| ▸ | MAPT | P10636 | 1/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.84 |
| ▸ | GLA | P06280 | 3/20 | 0.84 |
| ▸ | TP53 | P04637 | 2/20 | 0.84 |
| ▸ | HPGD | P15428 | 2/20 | 0.84 |
| ▸ | MEN1 | O00255 | 2/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.84 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.84 |
| ▸ | HTT | P42858 | 2/20 | 0.84 |
| ▸ | STAT6 | P42226 | 1/20 | 0.84 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.84 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rs-9-Aminocamptothecin SCHEMBL8715088 | 0.96 | TOP1 (1.00) | TOP1KDM4ERAB9ABLMRECQL | |
| 9-Aminocamptothecin SCHEMBL29369669 | 0.96 | TOP1 (1.00) | TOP1KDM4ERAB9ABLMRECQL | |
| 9-Aminocamptothecin SCHEMBL26578 | 0.96 | TOP1 (1.00) | TOP1KDM4ERAB9ABLMRECQL | |
| Camptothecin SCHEMBL29360250 | 0.92 | TOP1 (1.00) | TOP1KDM4ERAB9ABLMRECQL | |
| Camptothecin SCHEMBL6038 | 0.92 | TOP1 (1.00) | TOP1KDM4ERAB9ABLMRECQL | |
| Camptothecin SCHEMBL29369924 | 0.92 | TOP1 (1.00) | TOP1KDM4ERAB9ABLMRECQL | |
| Camptothecin SCHEMBL788063 | 0.92 | TOP1 (1.00) | TOP1KDM4ERAB9ABLMRECQL | |
| Camptothecin SCHEMBL29351099 | 0.92 | TOP1 (1.00) | TOP1KDM4ERAB9ABLMRECQL | |
| Camptothecin SCHEMBL4304557 | 0.92 | TOP1 (1.00) | TOP1KDM4ERAB9ABLMRECQL | |
| Camptothecin SCHEMBL2298909 | 0.92 | TOP1 (1.00) | TOP1KDM4ERAB9ABLMRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101083995-A | Cancer treatment method | SMITHKLINE BEECHAM CORK LTD (IE) | 2007-12-05 | — | — | CN | disclosed |