Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 4/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30507099 | 0.91 | TRIM24 (0.42) | TRIM24MAOAMAOBCYP11B1CYP11B2 | |
| SCHEMBL25316176 | 0.91 | TRIM24 (0.42) | TRIM24MAOAMAOBCYP11B1CYP11B2 | |
| SCHEMBL30506913 | 0.89 | TRIM24 (0.42) | TRIM24MAOAMAOBDRD2CYP11B1 | |
| SCHEMBL25314493 | 0.89 | TRIM24 (0.42) | TRIM24MAOAMAOBDRD2CYP11B1 | |
| SCHEMBL30507216 | 0.89 | TRIM24 (0.42) | TRIM24MAOAMAOBDRD2CYP11B1 | |
| SCHEMBL25314491 | 0.89 | TRIM24 (0.42) | TRIM24MAOAMAOBDRD2CYP11B1 | |
| SCHEMBL25317167 | 0.89 | TRIM24 (0.42) | TRIM24MAOAMAOBDRD2CYP11B1 | |
| SCHEMBL26024620 | 0.83 | KCNH2 (0.37) | MAOAMAOBMET | |
| SCHEMBL26024619 | 0.81 | MAOA (0.36) | TRIM24MAOAMAOBDRD2DRD4 | |
| SCHEMBL26048760 | 0.80 | MAOA (0.44) | MAOAMAOBDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |