Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.62 |
| ▸ | CCKBR | P32239 | 3/20 | 0.57 |
| ▸ | F10 | P00742 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | RHOA | P61586 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3443750 | 0.90 | PARP1 (0.62) | PARP1F10NPSR1KMT2AGAA | |
| SCHEMBL3443753 | 0.90 | PARP1 (0.62) | PARP1F10NPSR1KMT2AGAA | |
| SCHEMBL13106468 | 0.90 | PARP1 (0.62) | PARP1F10NPSR1KMT2AGAA | |
| SCHEMBL276588 | 0.84 | KMT2A (0.57) | CCKBRNPSR1TSHRRHOAKMT2A | |
| SCHEMBL12771582 | 0.83 | ENPP2 (0.65) | CCKBRFAAHKMT2AALDH1A1 | |
| Toluene SCHEMBL27971647 | 0.82 | SMN1; SMN2 (0.63) | NPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL4130473 | 0.82 | SMN1; SMN2 (0.58) | PARP1NPSR1KMT2AGAAMEN1 | |
| SCHEMBL4004604 | 0.80 | HTT (0.58) | PARP1KMT2AGAAALDH1A1 | |
| SCHEMBL20129713 | 0.79 | SMN1; SMN2 (0.59) | TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL1441223 | 0.79 | SMN1; SMN2 (0.59) | TSHRKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067586-B2 | Fused heteroaryl derivatives | ASTELLAS PHARMA INC. (JP) | 2011-11-29 | — | — | US | disclosed |
| US-20100137584-A1 | FUSED HETEROARYL DERIVATIVES | HAYAKAWA MASAHIKO | 2010-06-03 | — | — | US | disclosed |
| US-20100137585-A1 | FUSED HETEROARYL DERIVATIVES | HAYAKAWA MASAHIKO | 2010-06-03 | — | — | US | disclosed |
| US-20070037805-A1 | Fused heteroaryl derivatives | HAYAKAWA MASAHIKO | 2007-02-15 | — | — | US | disclosed |
| US-7173029-B2 | Fused heteroaryl derivatives | ASTELLAS PHARMA INC. (JP) | 2007-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137584-A1 | FUSED HETEROARYL DERIVATIVES | PIK3CD, PIK3R3, PIK3C2A | PARP1 1165/4885CCKBR 4035/4885F10 3558/4885 |
| US-20070037805-A1 | Fused heteroaryl derivatives | PIK3CD, PIK3R3, PIK3C2A | PARP1 1165/4885CCKBR 4035/4885F10 3558/4885 |
| US-20100137585-A1 | FUSED HETEROARYL DERIVATIVES | PIK3CD, PIK3R3, PIK3C2A | PARP1 1165/4885CCKBR 4035/4885F10 3558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.