Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.51 |
| ▸ | CCNC | P24863 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 7/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.39 |
| ▸ | PIM1 | P11309 | 6/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25935020 | 0.82 | CA12 (0.38) | CDK8CCNCCDK5CDK5R1CLK2 | |
| SCHEMBL25934785 | 0.81 | CDK7 (0.44) | CDK5CLK2DYRK1ACLK4DYRK3 | |
| SCHEMBL24137563 | 0.74 | CCNC (0.61) | CDK8CCNCCLK1FDPSGSK3B | |
| SCHEMBL25936162 | 0.72 | CCNC (0.54) | CDK8CCNCCLK1FDPSGSK3B | |
| SCHEMBL25934096 | 0.72 | CA12 (0.34) | CDK8CCNCCLK2DYRK1ACLK3 | |
| SCHEMBL24137732 | 0.70 | CCNC (0.54) | CDK8CCNCCLK1FDPSGSK3B | |
| SCHEMBL24137909 | 0.70 | CCNC (0.54) | CDK8CCNCCLK1GSK3BCDK5 | |
| SCHEMBL24137790 | 0.70 | CCNC (0.63) | CDK8CCNCCLK1GSK3BCDK5 | |
| SCHEMBL25933932 | 0.68 | DYRK1A (0.50) | CDK8CCNCCLK1FDPSGSK3B | |
| SCHEMBL25935349 | 0.68 | ITK (0.52) | CLK4AURKBFGFR1KDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234935-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234935-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | PACSIN2, MAP3K20, PHKG1 | CDK8 202/4885CCNC 571/4885CLK1 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.