SCHEMBL2593530

SCHEMBL2593530

Nc1c(Cl)cc(Cl)c(N)c1Cl

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.56
ALDH1A1 P00352 3/20 0.56
GAA P10253 1/20 0.44
CA1 P00915 3/20 0.42
CA2 P00918 3/20 0.42
CA9 Q16790 3/20 0.42
TSHR P16473 5/20 0.40
HPGD P15428 2/20 0.40
HSD17B10 Q99714 2/20 0.40
CASP1 P29466 1/20 0.40
POLB P06746 1/20 0.37
APEX1 P27695 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
MAPK1 P28482 2/20 0.37
AHR P35869 1/20 0.37
THRB P10828 1/20 0.36
TP53 P04637 2/20 0.35
CD44 P16070 1/20 0.35
NPC1 O15118 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7289940 0.87 CYP3A4 (0.59) CYP3A4ALDH1A1GAACA1CA2
SCHEMBL29674841 0.80 CYP3A4 (0.50) CYP3A4ALDH1A1GAACA1CA2
SCHEMBL31036910 0.80 CYP3A4 (0.43) CYP3A4ALDH1A1GAACA1CA2
SCHEMBL9189225 0.80 CYP3A4 (0.43) CYP3A4ALDH1A1GAACA1CA2
SCHEMBL11144843 0.80 HSD17B10 (0.59) CYP3A4ALDH1A1GAACA1CA2
SCHEMBL11843163 0.80 CD44 (0.44) CYP3A4ALDH1A1GAACA1CA2
SCHEMBL8780500 0.80 CA1 (0.48) CYP3A4ALDH1A1GAACA1CA2
SCHEMBL7221200 0.80 HSD17B10 (0.46) CYP3A4ALDH1A1GAACA1CA2
SCHEMBL1639902 0.79 CYP3A4 (0.56) CYP3A4ALDH1A1GAACA1CA2
SCHEMBL1503430 0.78 ALDH1A1 (0.48) CYP3A4ALDH1A1GAACA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111417649-B Vesicles incorporating transmembrane proteins 水通道蛋白有限公司 2024-04-26 CN disclosed
US-20230111073-A1 METHOD OF PREPARING A THIN FILM COMPOSITE LAYER AQUAPORIN A/S (DK) 2023-04-13 US disclosed
US-20230087170-A1 METHOD OF PREPARING A THIN FILM COMPOSITE LAYER AQUAPORIN A/S (DK) 2023-03-23 US disclosed
US-11421106-B2 Vesicle incorporating transmembrane protein AQUAPORIN A/S (DK) 2022-08-23 US disclosed
CN-110430937-B Diblock copolymer vesicles and separation membranes comprising aquaporin water channels and methods of making and using the same 水通道蛋白有限公司 2022-03-11 CN disclosed
EP-3700922-B1 VESICLE INCORPORATING TRANSMEMBRANE PROTEIN AQUAPORIN AS (DK) 2021-12-08 EP disclosed
US-11000809-B2 Diblock copolymer vesicles and separation membranes comprising aquaporin water channels and methods of making and using them AQUAPORIN A/S (DK) 2021-05-11 US disclosed
EP-3700922-A1 VESICLE INCORPORATING TRANSMEMBRANE PROTEIN Aquaporin A/S (DK) 2020-09-02 EP disclosed
US-20200239685-A1 VESICLE INCORPORATING TRANSMEMBRANE PROTEIN AQUAPORIN A/S (DK) 2020-07-30 US disclosed
CN-111417649-A Vesicles incorporating transmembrane proteins 水通道蛋白有限公司 2020-07-14 CN disclosed
EP-2569081-B1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME AIR PROD & CHEM (US) 2017-08-23 EP disclosed
US-8926733-B2 Polymers, polymer membranes and methods of producing the same AIR PRODUCTS AND CHEMICALS, INC. (US) 2015-01-06 US disclosed
EP-2569081-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME Air Products and Chemicals, Inc. (US) 2013-03-20 EP disclosed
US-20130047844-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2013-02-28 US disclosed
WO-2011143530-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2011-11-17 WO disclosed
EP-0477440-B1 Self-locking agent THREE BOND CO LTD (JP) 1997-12-03 EP disclosed
US-5352308-A Self-locking agent THREE BOND CO., LTD. (JP) 1994-10-04 US disclosed
EP-0477440-A1 Self-locking agent THREE BOND CO., LTD. (JP) 1992-04-01 EP disclosed
US-RE30351-E Aromatic polyimide, polyester and polyamide separation membranes E. I. DU PONT DE NEMOURS AND COMPANY (US) 1980-07-29 US disclosed
US-4144225-A Novel aromatic diamine compounds and flame-resistant polyamide compositions containing said compounds KANEBO, LTD. (JP) 1979-03-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230111073-A1 METHOD OF PREPARING A THIN FILM COMPOSITE LAYER CHMP4B, VMA21, VAMP8 CYP3A4 4570/4885ALDH1A1 4599/4885GAA 2591/4885
US-20230087170-A1 METHOD OF PREPARING A THIN FILM COMPOSITE LAYER CHMP4B, VMA21, VAMP8 CYP3A4 4570/4885ALDH1A1 4599/4885GAA 2591/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.