Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20989156 | 0.81 | LMNA (0.65) | LMNASMN1; SMN2TSHRHPGDGAA | |
| SCHEMBL15134842 | 0.80 | SMN1; SMN2 (0.83) | LMNASMN1; SMN2TSHRHPGDGAA | |
| SCHEMBL20989308 | 0.80 | KMT2A (0.56) | SMN1; SMN2HPGDMAPK1MEN1KMT2A | |
| SCHEMBL25935735 | 0.79 | LMNA (0.62) | LMNASMN1; SMN2TSHRHPGDGAA | |
| SCHEMBL652306 | 0.79 | SMN1; SMN2 (0.77) | LMNASMN1; SMN2TSHRHPGDGAA | |
| SCHEMBL15337901 | 0.77 | SMN1; SMN2 (0.60) | LMNASMN1; SMN2TSHRHPGDGAA | |
| SCHEMBL10245179 | 0.77 | SMN1; SMN2 (0.77) | LMNASMN1; SMN2TSHRHPGDGAA | |
| SCHEMBL25935737 | 0.77 | SMN1; SMN2 (0.77) | LMNASMN1; SMN2TSHRHPGDGAA | |
| SCHEMBL5064619 | 0.76 | LMNA (0.76) | LMNASMN1; SMN2TSHRHPGDGAA | |
| SCHEMBL24893071 | 0.75 | LMNA (0.74) | LMNASMN1; SMN2TSHRHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242548-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242548-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | KRAS, HRAS, NRAS | LMNA 2600/4885SMN1; SMN2 3432/4885TSHR 4752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.