Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | TARS1 | P26639 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | PRF1 | P14222 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594355 | 0.88 | MAPKAPK2 (0.39) | GSK3BTARS1MAPKAPK2DAPK3NTRK1 | |
| SCHEMBL14737469 | 0.84 | HPGD (0.46) | GSK3BMAPKAPK2HPGDTDP2PRF1 | |
| SCHEMBL2593336 | 0.82 | HPGD (0.44) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL2589583 | 0.81 | HPGD (0.45) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL14736918 | 0.81 | GSK3B (0.41) | GSK3BTARS1MAPKAPK2DAPK3NTRK1 | |
| SCHEMBL2593374 | 0.80 | PRF1 (0.40) | GSK3BTARS1MAPKAPK2DAPK3NTRK1 | |
| SCHEMBL14737138 | 0.80 | HPGD (0.44) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL14737111 | 0.79 | TDP2 (0.39) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL2589744 | 0.79 | MAPKAPK2 (0.39) | GSK3BTARS1MAPKAPK2DAPK3NTRK1 | |
| SCHEMBL2590843 | 0.79 | MAPT (0.41) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | claimed |