⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25993969 | 0.75 | SLC6A2 (0.36) | — | |
| SCHEMBL25993020 | 0.75 | SLC6A2 (0.33) | — | |
| SCHEMBL25999425 | 0.74 | OPRK1 (0.30) | — | |
| SCHEMBL26021674 | 0.74 | PDK2 (0.33) | — | |
| SCHEMBL25997042 | 0.69 | HCRTR1 (0.30) | — | |
| SCHEMBL26000356 | 0.69 | — | — | |
| SCHEMBL25937581 | 0.66 | — | — | |
| SCHEMBL25994609 | 0.66 | — | — | |
| SCHEMBL25938867 | 0.66 | IKZF1 (0.34) | — | |
| SCHEMBL25994377 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820574-B1 | 3-(5-AMINO-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |