Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.57 |
| ▸ | RELA | Q04206 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25938119 | 1.00 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| Hydrochloric Acid SCHEMBL25334213 | 0.99 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| Hydrochloric Acid SCHEMBL25334221 | 0.99 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL4916753 | 0.93 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL9892926 | 0.93 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL4916768 | 0.93 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL26807888 | 0.81 | MAOA (0.48) | NPC1RAB9ASMN1; SMN2MAPK1MEN1 | |
| SCHEMBL23389466 | 0.81 | MAPT (0.46) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL23389467 | 0.81 | MAPT (0.46) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL19844520 | 0.80 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |