Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RGS12 | O14924 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PNP | P00491 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | VEGFA | P15692 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21702894 | 0.81 | MAP4K1 (0.36) | MAP4K1ELANE | |
| SCHEMBL21702897 | 0.80 | MEN1 (0.38) | MAP4K1KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL21685522 | 0.79 | MAP4K1 (0.45) | MAP4K1 | |
| SCHEMBL21702899 | 0.75 | MAP4K1 (0.46) | MAP4K1KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL25949320 | 0.74 | MAP4K1 (0.34) | MAP4K1KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL21685592 | 0.73 | MAP4K1 (0.46) | MAP4K1ELANE | |
| SCHEMBL21703101 | 0.73 | MAP4K1 (0.41) | MAP4K1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL21703150 | 0.71 | MAP4K1 (0.46) | MAP4K1KDM4EALDH1A1 | |
| SCHEMBL25938179 | 0.71 | MAP4K1 (0.35) | MAP4K1KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL25938742 | 0.70 | MAP4K1 (0.39) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219460-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | Sitari Pharma, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |