Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 14/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21703103 | 0.87 | MAP4K1 (0.44) | MAP4K1PKMKDM4EMEN1ALDH1A1 | |
| SCHEMBL23452918 | 0.85 | MAP4K1 (0.41) | MAP4K1ELANEPARP1PKM | |
| SCHEMBL21703430 | 0.82 | P2RX3 (0.33) | MAP4K1 | |
| SCHEMBL21702894 | 0.81 | MAP4K1 (0.36) | MAP4K1ELANEPARP1 | |
| SCHEMBL25938179 | 0.78 | MAP4K1 (0.35) | MAP4K1ELANEPARP1KDM4EMEN1 | |
| SCHEMBL25952900 | 0.76 | MAP4K1 (0.51) | MAP4K1ELANEPARP1PKM | |
| SCHEMBL25952784 | 0.76 | MAP4K1 (0.55) | MAP4K1 | |
| SCHEMBL21703026 | 0.75 | MAP4K1 (0.50) | MAP4K1ELANEPARP1KDM4EALDH1A1 | |
| SCHEMBL25938264 | 0.73 | MAP4K1 (0.36) | MAP4K1ELANEKDM4EMEN1ALDH1A1 | |
| SCHEMBL21703240 | 0.73 | MAP4K1 (0.35) | MAP4K1ELANEPARP1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219460-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | Sitari Pharma, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2020033784-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | SITARI PHARMA, INC. (US) | 2020-02-13 | — | — | WO | disclosed |