Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.30 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26024428 | 0.84 | TLR8 (0.36) | TLR8 | |
| SCHEMBL25313492 | 0.84 | TLR8 (0.36) | TLR8 | |
| SCHEMBL26022451 | 0.73 | TLR8 (0.34) | TLR8MAP3K12 | |
| SCHEMBL25904920 | 0.72 | PDK2 (0.34) | TLR8 | |
| SCHEMBL31436566 | 0.64 | — | — | |
| SCHEMBL31067863 | 0.64 | HPGD (0.33) | — | |
| SCHEMBL25923360 | 0.64 | TLR8 (0.38) | TLR8TLR7 | |
| SCHEMBL25216639 | 0.64 | HPGD (0.33) | — | |
| SCHEMBL25317472 | 0.64 | TLR8 (0.42) | TLR8TLR7 | |
| SCHEMBL31436563 | 0.63 | AR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |