Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betahistine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betahistine SCHEMBL2589993 | 1.00 | HRH3 (0.73) | HRH3ALDH1A1LMNATAAR1ALOX15 | |
| Betahistine SCHEMBL9319520 | 1.00 | HRH3 (0.73) | HRH3ALDH1A1LMNATAAR1ALOX15 | |
| Betahistine SCHEMBL20421888 | 0.89 | HRH3 (0.80) | HRH3ALDH1A1LMNATAAR1ALOX15 | |
| Betahistine SCHEMBL20421883 | 0.89 | HRH3 (0.80) | HRH3ALDH1A1LMNATAAR1ALOX15 | |
| Betahistine SCHEMBL9321873 | 0.88 | HRH3 (0.77) | HRH3ALDH1A1LMNATAAR1ALOX15 | |
| Betahistine SCHEMBL2594682 | 0.86 | HRH3 (0.75) | HRH3ALDH1A1LMNATAAR1ALOX15 | |
| Betahistine SCHEMBL125582 | 0.85 | HRH3 (1.00) | HRH3ALDH1A1LMNATAAR1ALOX15 | |
| Betahistine SCHEMBL28346535 | 0.85 | HRH3 (1.00) | HRH3ALDH1A1LMNATAAR1ALOX15 | |
| Betahistine SCHEMBL29354603 | 0.85 | HRH3 (1.00) | HRH3ALDH1A1LMNATAAR1ALOX15 | |
| Phthalic Acid SCHEMBL2594470 | 0.85 | HRH3 (0.73) | HRH3ALDH1A1LMNATAAR1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3474850-A1 | INTRANASAL COMPOSITION COMPRISING BETAHISTINE | Otolanum AG (CH) | 2019-05-01 | — | — | EP | claimed |
| WO-2018141922-A1 | INTRANASAL COMPOSITION COMPRISING BETAHISTINE | OTOLANUM AG (CH) | 2018-08-09 | — | — | WO | claimed |
| US-20180214432-A1 | PHARMACEUTICAL COMPOSITION COMPRISING BETAHISTINE | OTOLANUM AG (CH) | 2018-08-02 | — | — | US | claimed |
| EP-0397025-B1 | [2-(2-pyridyl)ethyl]-methylamine salts | PRODOTTI FORMENTI (IT) | 1994-01-12 | — | — | EP | claimed |
| EP-0397025-A1 | [2-(2-pyridyl)ethyl]-methylamine salts | PRODOTTI FORMENTI S.r.l. (IT) | 1990-11-14 | — | — | EP | claimed |
| EP-3698791-B1 | INTRANASAL COMPOSITION COMPRISING BETAHISTINE | OTOLANUM AG (CH) | 2023-10-25 | — | — | EP | disclosed |
| EP-3698791-A1 | INTRANASAL COMPOSITION COMPRISING BETAHISTINE | Otolanum AG (CH) | 2020-08-26 | — | — | EP | disclosed |
| EP-3474850-B1 | INTRANASAL COMPOSITION COMPRISING BETAHISTINE | OTOLANUM AG (CH) | 2020-04-22 | — | — | EP | disclosed |
| US-10456386-B2 | Pharmaceutical composition comprising betahistine | OTOLANUM AG (CH) | 2019-10-29 | — | — | US | disclosed |
| EP-3474850-A1 | INTRANASAL COMPOSITION COMPRISING BETAHISTINE | Otolanum AG (CH) | 2019-05-01 | — | — | EP | disclosed |
| WO-2018141922-A1 | INTRANASAL COMPOSITION COMPRISING BETAHISTINE | OTOLANUM AG (CH) | 2018-08-09 | — | — | WO | disclosed |
| US-20180214432-A1 | PHARMACEUTICAL COMPOSITION COMPRISING BETAHISTINE | OTOLANUM AG (CH) | 2018-08-02 | — | — | US | disclosed |
| WO-2011139250-A2 | WATER DISPERSIBLE FORMULATION | BILGIC MAHMUT (TR) | 2011-11-10 | — | — | WO | disclosed |
| EP-0397025-B1 | [2-(2-pyridyl)ethyl]-methylamine salts | PRODOTTI FORMENTI (IT) | 1994-01-12 | — | — | EP | disclosed |
| EP-0397025-A1 | [2-(2-pyridyl)ethyl]-methylamine salts | PRODOTTI FORMENTI S.r.l. (IT) | 1990-11-14 | — | — | EP | disclosed |