Betahistine

Betahistine

SCHEMBL125582

CNCCc1ccccn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH1HRH3

The experimentally established mechanism targets of Betahistine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HRH3 known ✓ Q9Y5N1 1/20 1.00
HRH1 known ✓ P35367 2/20 0.55
LMNA P02545 2/20 0.96
ALDH1A1 P00352 2/20 0.96
TAAR1 Q96RJ0 2/20 0.96
ALOX15 P16050 1/20 0.96
TDP1 Q9NUW8 1/20 0.80
CYP1A2 P05177 3/20 0.61
CYP2C19 P33261 1/20 0.61
APP P05067 3/20 0.55
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53
CYP2D6 P10635 1/20 0.50
ATM Q13315 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Betahistine SCHEMBL29354603 1.00 HRH3 (1.00) HRH3LMNAALDH1A1TAAR1ALOX15
Betahistine SCHEMBL28346535 1.00 HRH3 (1.00) HRH3LMNAALDH1A1TAAR1ALOX15
Betahistine SCHEMBL20421889 0.98 HRH3 (0.96) HRH3LMNAALDH1A1TAAR1ALOX15
Betahistine SCHEMBL20639365 0.98 HRH3 (0.96) HRH3LMNAALDH1A1TAAR1ALOX15
Betahistine SCHEMBL11315542 0.98 HRH3 (0.96) HRH3LMNAALDH1A1TAAR1ALOX15
Betahistine SCHEMBL60646 0.98 LMNA (1.00) HRH3LMNAALDH1A1TAAR1ALOX15
Betahistine SCHEMBL20421886 0.98 HRH3 (0.96) HRH3LMNAALDH1A1TAAR1ALOX15
Betahistine SCHEMBL654358 0.98 LMNA (1.00) HRH3LMNAALDH1A1TAAR1ALOX15
Betahistine SCHEMBL1649204 0.98 HRH3 (0.96) HRH3LMNAALDH1A1TAAR1ALOX15
Betahistine SCHEMBL5373612 0.96 LMNA (0.96) HRH3LMNAALDH1A1TAAR1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5731 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122036817-A C-alkyl carbon glycoside and preparation method thereof 江西师范大学 2026-05-15 CN claimed
EP-4731194-A1 MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT CSP Technologies, Inc. (US) 2026-04-29 EP claimed
EP-4704971-A1 GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY Cognito Therapeutics, Inc. (US) 2026-03-11 EP claimed
EP-4687805-A1 MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING ACTIVATED CARBON OR A DERIVATIVE THEREOF CSP Technologies, Inc. (US) 2026-02-11 EP claimed
US-20260027008-A1 MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING ACTIVATED CARBON OR A DERIVATIVE THEREOF CSP TECHNOLOGIES, INC. 2026-01-29 US claimed
EP-4673146-A2 METHODS FOR TREATING OBSESSIVE COMPULSIVE RELATED DISORDERS, TIC DISORDERS AND GLUTAMATE EXCITOTOXICITY RELATED DISORDERS Biohaven Therapeutics Ltd. (VG) 2026-01-07 EP claimed
WO-2025264260-A1 MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT CSP TECHNOLOGIES, INC. (US) 2025-12-26 WO claimed
US-12472186-B2 Pharmaceutical compositions and methods of treating cardiovascular diseases Cardix Therapeutics LLC (US) 2025-11-18 US claimed
EP-4633614-A1 STABLE PHARMACEUTICAL COMPOSITION OF AN AMINE DRUG Sun Pharmaceutical Industries Limited (IN) 2025-10-22 EP claimed
US-20250255781-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-08-14 US claimed
EP-0397025-B1 [2-(2-pyridyl)ethyl]-methylamine salts PRODOTTI FORMENTI (IT) 1994-01-12 EP claimed
US-5221535-A Sustained release formulations of insect repellent NOVA PHARMACEUTICAL CORPORATION (US) 1993-06-22 US claimed
EP-0502119-A1 LIPOSPHERES FOR CONTROLLED DELIVERY OF SUBSTANCES. NOVA PHARM CORP (US) 1992-09-09 EP claimed
EP-0502642-A1 Sustained release compositions RECKITT AND COLMAN PRODUCTS LIMITED (GB) 1992-09-09 EP claimed
US-5132115-A PLANAR THERAPEUTIC SYSTEM, PROCESS FOR ITS PRODUCTION AND UTILIZATION LOHMANN GMBH & CO., KG, A GERMAN CORP. (DE) 1992-07-21 US claimed
EP-0242827-B1 SURFACE SHAPED THERAPEUTIC SYSTEM, METHOD FOR ITS MANUFACTURE, AND ITS APPLICATION Lohmann GmbH & Co. KG (DE) 1991-12-27 EP claimed
WO-1991007171-A1 LIPOSPHERES FOR CONTROLLED DELIVERY OF SUBSTANCES NOVA PHARMACEUTICAL CORPORATION (US) 1991-05-30 WO claimed
EP-0397025-A1 [2-(2-pyridyl)ethyl]-methylamine salts PRODOTTI FORMENTI S.r.l. (IT) 1990-11-14 EP claimed
US-4395311-A Preparation of aminomethanols THE DOW CHEMICAL COMPANY (US) 1983-07-26 US claimed
US-4159332-A Prevention of or reduction in severity of myocardial infarction UNIMED, INC. (US) 1979-06-26 US claimed