Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21684352 | 0.90 | FAAH (0.38) | MAP4K1FAAHTRPV3NR1H2 | |
| SCHEMBL21685143 | 0.83 | MAP4K1 (0.47) | MAP4K1FAAHNR1H2 | |
| SCHEMBL21703007 | 0.72 | NR1H2 (0.38) | FAAHTRPV3NR1H2HSP90AA1HSP90AB1 | |
| SCHEMBL4385302 | 0.72 | TBXA2R (0.46) | FAAH | |
| SCHEMBL21685572 | 0.72 | NR1H2 (0.39) | FAAHTRPV3NR1H2HSP90AA1HSP90AB1 | |
| SCHEMBL21685330 | 0.71 | MAP4K1 (0.38) | MAP4K1 | |
| SCHEMBL21684418 | 0.71 | MAP4K1 (0.47) | MAP4K1 | |
| SCHEMBL21685684 | 0.70 | MAP4K1 (0.37) | MAP4K1 | |
| SCHEMBL21703142 | 0.69 | MAP4K1 (0.47) | MAP4K1 | |
| SCHEMBL4716718 | 0.69 | BRD4 (0.44) | MAP4K1FAAHNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219460-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | Sitari Pharma, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |