Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.62 |
| ▸ | DDB1 | Q16531 | 12/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.50 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25814228 | 0.80 | CRBN (0.72) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL24062189 | 0.79 | IKZF2 (0.68) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL1399131 | 0.77 | CRBN (1.00) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL31741887 | 0.77 | CRBN (1.00) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL776766 | 0.77 | CRBN (1.00) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL1398958 | 0.77 | CRBN (1.00) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| Thalidomide SCHEMBL411175 | 0.74 | CRBN (1.00) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| Thalidomide SCHEMBL411178 | 0.74 | CRBN (1.00) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| Thalidomide SCHEMBL7581 | 0.74 | CRBN (1.00) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| Thalidomide SCHEMBL571278 | 0.74 | CRBN (1.00) | CRBNDDB1ALDH1A1CHRM2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820574-B1 | 3-(5-AMINO-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |