Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FHIT | P49789 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20471481 | 0.79 | KDM4E (0.74) | KDM4EMAPTKMT2APOLBPDE4D | |
| SCHEMBL17777909 | 0.76 | KDM4E (0.55) | KDM4EMAPTKMT2APOLBPDE4D | |
| SCHEMBL4650523 | 0.76 | KDM4E (0.55) | KDM4EMAPTKMT2APOLBPDE4D | |
| SCHEMBL4650539 | 0.74 | KDM4E (0.52) | KDM4EMAPTKMT2APOLBPDE4D | |
| SCHEMBL4650693 | 0.74 | KDM4E (0.52) | KDM4EMAPTKMT2APOLBPDE4D | |
| SCHEMBL4125363 | 0.73 | SMN1; SMN2 (0.50) | KDM4EMAPTKMT2APOLBPDE4D | |
| SCHEMBL7470961 | 0.73 | PDE4D (0.65) | KDM4EMAPTKMT2APOLBPDE4D | |
| SCHEMBL20471495 | 0.72 | KDM4E (0.50) | KDM4EMAPTKMT2APOLBPDE4D | |
| SCHEMBL3848316 | 0.71 | KDM4E (0.52) | KDM4EMAPTKMT2APOLBPDE4D | |
| SCHEMBL4650633 | 0.71 | KDM4E (0.49) | KDM4EMAPTKMT2APOLBPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566866-A1 | 4 SUBSTITUTED PYRAZOLOPYRIMIDINES USEFUL AS PKC-THETA INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011139273-A1 | 4 SUBSTITUTED PYRAZOLOPYRIMIDINES USEFUL AS PKC-THETA INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-10 | — | — | WO | disclosed |