Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737202 | 0.88 | PDE4D (0.43) | PDE4DL3MBTL1ALDH1A1HPGDCASP1 | |
| SCHEMBL2588005 | 0.86 | PDE4D (0.42) | PDE4DL3MBTL1ALDH1A1HPGDCASP1 | |
| SCHEMBL2585452 | 0.86 | PDE4D (0.38) | PDE4DMAOBMEN1KMT2A | |
| SCHEMBL2591497 | 0.81 | PDE4D (0.41) | PDE4DL3MBTL1MAOBMEN1KMT2A | |
| SCHEMBL2591854 | 0.79 | PDE4D (0.40) | PDE4DL3MBTL1MAOBMEN1KMT2A | |
| SCHEMBL2588531 | 0.79 | PDE4D (0.37) | PDE4DL3MBTL1MAOBMEN1KMT2A | |
| SCHEMBL2593499 | 0.78 | PDE4D (0.55) | PDE4D | |
| SCHEMBL2593047 | 0.77 | PDE4D (0.41) | PDE4DMAOBMEN1KMT2AKDM4E | |
| SCHEMBL2593496 | 0.77 | PDE4D (0.36) | PDE4DL3MBTL1MAOBKDM4ELMNA | |
| SCHEMBL14736739 | 0.77 | PDE4D (0.43) | PDE4DMAOBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |