Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.42 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588997 | 0.79 | KDM4E (0.46) | ICMTSMN1; SMN2POLBTSHRHTT | |
| SCHEMBL13106217 | 0.79 | GRM4 (0.43) | ICMTSSTR4KDM4C | |
| SCHEMBL15093813 | 0.78 | MAP3K14 (0.44) | SSTR4KDM4CIDO1TDO2 | |
| SCHEMBL31429419 | 0.78 | MAP3K14 (0.44) | SSTR4KDM4CIDO1TDO2 | |
| SCHEMBL1163228 | 0.77 | ATM (0.37) | ICMTSMN1; SMN2POLBTSHRNR2F2 | |
| SCHEMBL19570373 | 0.74 | SSTR4 (0.35) | ICMTSMN1; SMN2POLBTSHRNR2F2 | |
| SCHEMBL20646913 | 0.73 | L3MBTL1 (0.44) | SMN1; SMN2HTTSSTR4KDM4CIDO1 | |
| SCHEMBL29805505 | 0.73 | KDM4C (0.49) | SMN1; SMN2SSTR4KDM4CIDO1TDO2 | |
| SCHEMBL30579705 | 0.72 | HTR2A (0.41) | ICMTSMN1; SMN2POLBTSHRNR2F2 | |
| Trifluoroacetic Acid SCHEMBL15093796 | 0.72 | SCN9A (0.44) | SSTR4KDM4CIDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |