Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 18/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25947829 | 0.89 | MAP4K1 (0.51) | MAP4K1AKR1B1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL25947667 | 0.88 | MAP4K1 (0.70) | MAP4K1AKR1B1 | |
| SCHEMBL21683935 | 0.83 | MAP4K1 (0.72) | MAP4K1 | |
| SCHEMBL21683932 | 0.83 | MAP4K1 (0.72) | MAP4K1 | |
| SCHEMBL21683929 | 0.83 | MAP4K1 (0.72) | MAP4K1 | |
| SCHEMBL25947405 | 0.82 | MAP4K1 (0.50) | MAP4K1 | |
| SCHEMBL23453101 | 0.81 | MAP4K1 (0.85) | MAP4K1 | |
| SCHEMBL28598398 | 0.81 | MAP4K1 (0.85) | MAP4K1 | |
| SCHEMBL28598400 | 0.81 | MAP4K1 (0.85) | MAP4K1 | |
| SCHEMBL25947520 | 0.81 | MAP4K1 (0.50) | MAP4K1AKR1B1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219460-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | Sitari Pharma, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |