Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25947664 | 0.89 | MAP4K1 (0.57) | MAP4K1ALDH1A1L3MBTL1AKR1B1KDM4E | |
| SCHEMBL25947802 | 0.89 | MAP4K1 (0.64) | MAP4K1LMNAMAPTPKMHTT | |
| SCHEMBL25947520 | 0.83 | MAP4K1 (0.50) | MAP4K1PKMHTTALDH1A1HSD17B10 | |
| SCHEMBL21684311 | 0.82 | MAP4K1 (0.66) | MAP4K1 | |
| SCHEMBL21684305 | 0.82 | MAP4K1 (0.66) | MAP4K1 | |
| SCHEMBL21684298 | 0.82 | MAP4K1 (0.66) | MAP4K1 | |
| SCHEMBL25947458 | 0.81 | MAP4K1 (0.61) | MAP4K1ALDH1A1HSD17B10TSHR | |
| SCHEMBL25947483 | 0.81 | MAP4K1 (0.62) | MAP4K1 | |
| SCHEMBL25947821 | 0.81 | MAP4K1 (0.40) | MAP4K1LMNAMEN1KMT2APOLB | |
| SCHEMBL25947405 | 0.78 | MAP4K1 (0.50) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219460-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | Sitari Pharma, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |