Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 0.56 |
| ▸ | BRD4 | O60885 | 4/20 | 0.52 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.46 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.46 |
| ▸ | EED | O75530 | 3/20 | 0.43 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.43 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.43 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17956123 | 0.93 | EZH2 (0.50) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL2593985 | 0.91 | EZH2 (0.61) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL14716878 | 0.87 | EZH2 (0.70) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL2588268 | 0.86 | EZH2 (0.75) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL31158046 | 0.86 | EZH2 (0.75) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL17956122 | 0.85 | EZH2 (0.43) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL12180271 | 0.84 | EZH2 (0.63) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL2592955 | 0.84 | EZH2 (0.62) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL16726588 | 0.83 | EZH2 (0.40) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL2594710 | 0.82 | EZH2 (0.59) | EZH2BRD4BRD2BRD3BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | claimed |
| EP-2773754-B1 | Compounds for use in the treatment of T-cell mediated diseases | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2016-08-03 | — | — | EP | claimed |
| US-9402836-B2 | Indoles | GLAXOSMITHKLINE LLC (US) | 2016-08-02 | — | — | US | claimed |
| US-20150313887-A1 | INDOLES | GLAXOSMITHKLINE LLC | 2015-11-05 | — | — | US | claimed |
| US-8975291-B2 | Indoles | GLAXOSMITHKLINE LLC (US) | 2015-03-10 | — | — | US | claimed |
| US-20130345200-A1 | INDOLES | GLAXOSMITHKLINE LLC (US) | 2013-12-26 | — | — | US | claimed |
| EP-2566327-A1 | INDOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | claimed |
| WO-2011140324-A1 | INDOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | claimed |
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |
| US-9649307-B2 | Indoles | GLAXOSMITHKLINE LLC (US) | 2017-05-16 | — | — | US | disclosed |
| US-9649307-B2 | Indoles | GLAXOSMITHKLINE LLC (US) | 2017-05-16 | — | — | US | disclosed |
| US-9649307-B2 | Indoles | GLAXOSMITHKLINE LLC (US) | 2017-05-16 | — | — | US | disclosed |
| US-20160296518-A1 | INDOLES | GLAXOSMITHKLINE LLC | 2016-10-13 | — | — | US | disclosed |
| US-20160296518-A1 | INDOLES | GLAXOSMITHKLINE LLC | 2016-10-13 | — | — | US | disclosed |
| US-8536179-B2 | Indoles | GLAXOSMITHKLINE LLC (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536179-B2 | Indoles | GLAXOSMITHKLINE LLC (US) | 2013-09-17 | — | — | US | disclosed |
| US-20130053397-A1 | INDOLES | GLAXOSMITHKLINE LLC | 2013-02-28 | — | — | US | disclosed |
| US-20130053397-A1 | INDOLES | GLAXOSMITHKLINE LLC | 2013-02-28 | — | — | US | disclosed |
| US-20130053397-A1 | INDOLES | GLAXOSMITHKLINE LLC | 2013-02-28 | — | — | US | disclosed |
| WO-2011140324-A1 | INDOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150313887-A1 | INDOLES | IDO1, IDO2, INMT | EZH2 257/4885BRD4 190/4885BRD2 653/4885 |
| US-20130345200-A1 | INDOLES | IDO1, IDO2, INMT | EZH2 257/4885BRD4 190/4885BRD2 653/4885 |
| US-20130053397-A1 | INDOLES | IDO1, IDO2, INMT | EZH2 239/4885BRD4 177/4885BRD2 618/4885 |
| US-20160296518-A1 | INDOLES | IDO1, IDO2, INMT | EZH2 257/4885BRD4 190/4885BRD2 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.