Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SHBG | P04278 | 3/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15164706 | 1.00 | ESR1 (0.44) | ESR1LMNACYP3A4CYP2C19PGR | |
| SCHEMBL15164627 | 1.00 | ESR1 (0.44) | ESR1LMNACYP3A4CYP2C19PGR | |
| SCHEMBL15152963 | 1.00 | ESR1 (0.44) | ESR1LMNACYP3A4CYP2C19PGR | |
| SCHEMBL15153019 | 0.88 | CYP3A4 (0.57) | ESR1LMNACYP3A4CYP2C19PGR | |
| SCHEMBL12178065 | 0.88 | CYP3A4 (0.57) | ESR1LMNACYP3A4CYP2C19PGR | |
| SCHEMBL15164705 | 0.88 | CYP3A4 (0.57) | ESR1LMNACYP3A4CYP2C19PGR | |
| SCHEMBL15164626 | 0.88 | CYP3A4 (0.57) | ESR1LMNACYP3A4CYP2C19PGR | |
| SCHEMBL12178060 | 0.84 | SHBG (0.48) | ESR1LMNACYP3A4CYP2C19PGR | |
| SCHEMBL15164625 | 0.78 | SHBG (0.59) | ESR1LMNACYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL2590765 | 0.78 | SHBG (0.59) | ESR1LMNACYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566482-A1 | PROGESTERONE RECEPTOR ANTAGONISTS AND USES THEREOF | Institut National de la Santé et de la Recherche Médicale (FR) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011138460-A1 | PROGESTERONE RECEPTOR ANTAGONISTS AND USES THEREOF | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2011-11-10 | — | — | WO | disclosed |